Background glycogen storage disease type 1 gsd1 is a rare and genetically heterogeneous metabolic defect of gluconeogenesis due to mutations of either the g6pc gene gsd1a or the slc37a4 gene gsd1b osteopenia is a known complication of gsd1 objectives the aim of this study was to investigate the effects of poor metabolic control and or use of gsd1 specific treatments on bone mineral . Objective to investigate the prevalence of both calcium metabolism alterations and bone defects in children with celiac disease cd study design we studied 54 untreated patients with cd mean age 7 years we compared the serum concentration of calcium magnesium 25ohvitamin d3 alkaline phosphatase and parathyroid hormone pth of patients with cd with those of 60 healthy children. Usually only one or a few bones have the disease many people with pagets disease do not have symptoms however the bone changes can cause bone pain misshapen bones broken bones fractures problems in the joints near the bones with the disease with treatment many people can manage their symptoms improve pain control the effects of
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